�According to new research from the Monell Center, odors from skin can be used to identify basal cell carcinoma, the most common form of skin malignant neoplastic disease. The findings, presented at the 236th meeting of the American Chemical Society, may open doors to development of new methods to notice basal cadre carcinoma and other forms of skin cancer.
The researchers sampled air travel above base cell tumors and found a different profile of chemical compounds compared to skin situated at the same sites in salubrious control subjects.
"Our findings may someday allow doctors to screen for and diagnose skin cancers at very early stages," said Michelle Gallagher, PhD.
Human skin produces numerous airborne chemical molecules known as volatile organic compounds, or VOCs, many of which are odorous. In the study presented at the ACS, the researchers obtained VOC profiles from basal cell carcinoma sites in 11 patients and compared them to profiles from similar pelt sites in 11 sizable controls.
Both profiles contained the same array of chemicals; the difference involved the amounts of specific chemicals - some were increased and others decreased in samples from basal cubicle carcinoma sites.
The researchers design to characterise skin odor profiles associated with former forms of skin cancer, including squamous cell carcinoma and malignant melanoma, the about serious form of skin cancer.
To identify changes related to crab, the researchers first needful to identify a prescriptive profile for VOCs and to make up one's mind whether this profile varies as a function of age, grammatical gender or body site.
In research published on-line last month in the British Journal of Dermatology, Gallagher and collaborators sampled air to a higher place two skin sites - forearm and upper back - in 25 healthy male and female subjects, who ranged in age from 19 to 79.
Using gas chromatography-mass spectrometry techniques, they identified almost century different chemical compounds coming from skin. The normative skin profile varied 'tween the 2 body sites, with differences in both the types and concentrations of VOCs.
Aging did non influence the types of VOCs establish in the profiles; even so, certain chemicals were present in greater amounts in older versus younger subjects.
This work provides the number one comprehensive characterization of cutis volatile organic chemicals at sites other than the underarm in people of different ages and genders. Previous studies of human skin had used either male or female subjects and had only examined one skin area.
Implications of the research are wide-ranging. Together, the two studies may facilitate advance development of unexampled methods to analyze skin for signs of adapted health status.
"Chemical biomarkers may eventually do as objective clinical markers of disease if effective sensor engineering can be developed," aforesaid Monell analytical organic pill pusher George Preti, PhD.
Increased understanding of the chemicals related to to peel odor could also star to maturation of more effective anti-aging skin charge products.
Gallagher, a postdoctoral mate in Preti's laboratory at the time the research was through, currently is employed at Rohm and Haas, Spring House, PA.
Also contributing to the do work presented at the ACS were Charles Wysocki and Jae Kwak (Monell Center), Steven S. Fakharzadeh and Christopher J. Miller (University of Pennsylvania School of Medicine), Andrew I. Spielman and Xuming Sun (New York University College of Dentistry) and Chrysalyne D. Schmults (Dana Farber/Brigham and Women's Cancer Center).
Wysocki, Spielman, Sun, and James J. Leyden (University of Pennsylvania School of Medicine) contributed to inquiry published in the British Journal of Dermatology.
This research was funded, in part, by the National Institutes of Health and by Ms. Bonnie Hunt.
The Monell Chemical Senses Center is a nonprofit organization basic research institute based in Philadelphia, Pennsylvania. For 40 years, Monell has been the nation's leading research center focused on understanding the senses of smell and taste: how they function and move lives from before birth through old age. Using a multidisciplinary approach, scientists collaborate in the areas of: sense and perception, neuroscience and molecular biological science, environmental and occupational health, nutrition and appetite, wellness and well being, and chemical ecology and communicating. For more information around Monell, visit http://www.monell.org/.
Source: Leslie Stein
Monell Chemical Senses Center
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Friday, 29 August 2008
Saturday, 9 August 2008
Macca, Ringo scrap the plans of Beatles film release
Melbourne (ANI): Sir Paul McCartney and Ringo Starr have reportedly scrapped their plans of releasing the Beatles moving picture, 'Let It Be'. If sources ar to be believed, the two feature stopped the release of their plastic film, which highlights the band's internal rift, because it shows relations between the Fab Four in a less than positive light.
"There has been speak of Let It Be finally beingness released just now at that place has been a change of heart," Daily Express quoted an industry author as locution. "The Beatles are soundless a monolithic global brand and it's felt it won"t be helped if the public sees the darker side of the story.
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"There has been speak of Let It Be finally beingness released just now at that place has been a change of heart," Daily Express quoted an industry author as locution. "The Beatles are soundless a monolithic global brand and it's felt it won"t be helped if the public sees the darker side of the story.
More info
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