�According to new research from the Monell Center, odors from skin can be used to identify basal cell carcinoma, the most common form of skin malignant neoplastic disease. The findings, presented at the 236th meeting of the American Chemical Society, may open doors to development of new methods to notice basal cadre carcinoma and other forms of skin cancer.
The researchers sampled air travel above base cell tumors and found a different profile of chemical compounds compared to skin situated at the same sites in salubrious control subjects.
"Our findings may someday allow doctors to screen for and diagnose skin cancers at very early stages," said Michelle Gallagher, PhD.
Human skin produces numerous airborne chemical molecules known as volatile organic compounds, or VOCs, many of which are odorous. In the study presented at the ACS, the researchers obtained VOC profiles from basal cell carcinoma sites in 11 patients and compared them to profiles from similar pelt sites in 11 sizable controls.
Both profiles contained the same array of chemicals; the difference involved the amounts of specific chemicals - some were increased and others decreased in samples from basal cubicle carcinoma sites.
The researchers design to characterise skin odor profiles associated with former forms of skin cancer, including squamous cell carcinoma and malignant melanoma, the about serious form of skin cancer.
To identify changes related to crab, the researchers first needful to identify a prescriptive profile for VOCs and to make up one's mind whether this profile varies as a function of age, grammatical gender or body site.
In research published on-line last month in the British Journal of Dermatology, Gallagher and collaborators sampled air to a higher place two skin sites - forearm and upper back - in 25 healthy male and female subjects, who ranged in age from 19 to 79.
Using gas chromatography-mass spectrometry techniques, they identified almost century different chemical compounds coming from skin. The normative skin profile varied 'tween the 2 body sites, with differences in both the types and concentrations of VOCs.
Aging did non influence the types of VOCs establish in the profiles; even so, certain chemicals were present in greater amounts in older versus younger subjects.
This work provides the number one comprehensive characterization of cutis volatile organic chemicals at sites other than the underarm in people of different ages and genders. Previous studies of human skin had used either male or female subjects and had only examined one skin area.
Implications of the research are wide-ranging. Together, the two studies may facilitate advance development of unexampled methods to analyze skin for signs of adapted health status.
"Chemical biomarkers may eventually do as objective clinical markers of disease if effective sensor engineering can be developed," aforesaid Monell analytical organic pill pusher George Preti, PhD.
Increased understanding of the chemicals related to to peel odor could also star to maturation of more effective anti-aging skin charge products.
Gallagher, a postdoctoral mate in Preti's laboratory at the time the research was through, currently is employed at Rohm and Haas, Spring House, PA.
Also contributing to the do work presented at the ACS were Charles Wysocki and Jae Kwak (Monell Center), Steven S. Fakharzadeh and Christopher J. Miller (University of Pennsylvania School of Medicine), Andrew I. Spielman and Xuming Sun (New York University College of Dentistry) and Chrysalyne D. Schmults (Dana Farber/Brigham and Women's Cancer Center).
Wysocki, Spielman, Sun, and James J. Leyden (University of Pennsylvania School of Medicine) contributed to inquiry published in the British Journal of Dermatology.
This research was funded, in part, by the National Institutes of Health and by Ms. Bonnie Hunt.
The Monell Chemical Senses Center is a nonprofit organization basic research institute based in Philadelphia, Pennsylvania. For 40 years, Monell has been the nation's leading research center focused on understanding the senses of smell and taste: how they function and move lives from before birth through old age. Using a multidisciplinary approach, scientists collaborate in the areas of: sense and perception, neuroscience and molecular biological science, environmental and occupational health, nutrition and appetite, wellness and well being, and chemical ecology and communicating. For more information around Monell, visit http://www.monell.org/.
Source: Leslie Stein
Monell Chemical Senses Center
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Friday, 29 August 2008
Saturday, 9 August 2008
Macca, Ringo scrap the plans of Beatles film release
Melbourne (ANI): Sir Paul McCartney and Ringo Starr have reportedly scrapped their plans of releasing the Beatles moving picture, 'Let It Be'. If sources ar to be believed, the two feature stopped the release of their plastic film, which highlights the band's internal rift, because it shows relations between the Fab Four in a less than positive light.
"There has been speak of Let It Be finally beingness released just now at that place has been a change of heart," Daily Express quoted an industry author as locution. "The Beatles are soundless a monolithic global brand and it's felt it won"t be helped if the public sees the darker side of the story.
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"There has been speak of Let It Be finally beingness released just now at that place has been a change of heart," Daily Express quoted an industry author as locution. "The Beatles are soundless a monolithic global brand and it's felt it won"t be helped if the public sees the darker side of the story.
More info
Tuesday, 1 July 2008
Hans Zimmer, James Newton Howard
Artist: Hans Zimmer, James Newton Howard
Genre(s):
Soundtrack
Discography:
Batman Begins
Year:
Tracks: 12
Royksopp
Tuesday, 24 June 2008
Christian Hoff, Stockard Channing will star in Broadway's 'Pal Joey'
NEW YORK - Joey Evans, the womanizing title character of "Pal Joey," is getting ready for a return to Broadway, played this time around by Tony winner Christian Hoff.
The classic 1940 Richard Rodgers-Lorenz Hart musical will also star Stockard Channing as wealthy socialite Vera Simpson and Martha Plimpton as scheming blackmailer Gladys Bumps. The Roundabout Theatre Company production will open Dec. 11 at Studio 54, with previews beginning Nov. 14.
No word yet on who will sing "Zip," the striptease parody memorably recreated in the show's successful 1952 revival by Elaine Stritch. The score also features such Rodgers and Hart standards as "Bewitched (Bothered and Bewildered)," "I Could Write a Book" and "You Mustn't Kick It Around." A song cut from the original, "I'm Talking to My Pal," will be included in the new production.
Joe Mantello will direct the Roundabout revival, which will have choreography by Graciela Daniele. The original book by John O'Hara has been redone by Richard Greenberg, author of such plays as "Take Me Out" and "Three Days of Rain."
Hoff won a Tony Award for his portrayal of Tommy DeVito in "Jersey Boys." Channing has been seen in such plays as "Six Degrees of Separation," "The Lion in Winter" and "House of Blue Leaves," and in the television series "The West Wing," in which she played first lady Abby Bartlet.
"Pal Joey" is based on a series of short stories O'Hara wrote for The New Yorker about an opportunistic down-on-his-luck hoofer whose specialty is using people to get what he wants.
The original 1940 production starred Gene Kelly and Vivienne Segal. Some critics sniffed at its cynical, unsentimental outlook, but by the time of its first Broadway revival in 1952 (which starred Segal and Harold Lang) the show was an even bigger hit.
The musical's last New York appearance was a 1995 "Encores!" concert version starring Patti LuPone and Peter Gallagher.
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Wednesday, 11 June 2008
Bond star shooting film in Dublin
'Casino Royale' star Eva Green begins work on her new film 'Cracks' in Dublin today.
Along with Green, the film will also star 'Atonement's Juno Temple and '28 Weeks Later' actress Imogen Poots.
Set in a boarding school in 1930s England, the film tells the story of a girl's unhealthy bond with her teacher which is threatened by the arrival of a new student.
The film is an Irish-UK co-production, with the Irish company Element Pictures among the companies involved.
Speaking about the film Andrew Lowe of Element Pictures said: "We are particularly pleased that Jordan [Scott, director] has cast two 13-year-old Dublin girls, with no previous drama experience, Adele McCann and Zoe Carroll, for two key roles."
Scott is the daughter of legendary director Ridley Scott and is making her feature directing debut with 'Cracks'.
Her father's company, Scott Free, is also among the producers of the film.
'Cracks' will be shot in Ireland over the next seven weeks.
Along with Green, the film will also star 'Atonement's Juno Temple and '28 Weeks Later' actress Imogen Poots.
Set in a boarding school in 1930s England, the film tells the story of a girl's unhealthy bond with her teacher which is threatened by the arrival of a new student.
The film is an Irish-UK co-production, with the Irish company Element Pictures among the companies involved.
Speaking about the film Andrew Lowe of Element Pictures said: "We are particularly pleased that Jordan [Scott, director] has cast two 13-year-old Dublin girls, with no previous drama experience, Adele McCann and Zoe Carroll, for two key roles."
Scott is the daughter of legendary director Ridley Scott and is making her feature directing debut with 'Cracks'.
Her father's company, Scott Free, is also among the producers of the film.
'Cracks' will be shot in Ireland over the next seven weeks.
Wednesday, 4 June 2008
Catch "Iron Man" in his other fine roles
For more than a decade, Robert Downey Jr. has had "the most gifted actor of his generation" epoxied to his name. There was a time not so long ago when he also seemed to be caught in a continuous loop of addiction, incarceration and rehab. Now 43, he's turned his life around and actually seems to be living up to the accolade.
As the star of "Iron Man," Downey not only has the career advantage of being in a megahit, he is also a large reason for its success. How many great actors ever appear in these superhero lollapaloozas? More to the point, how many of them actually adorn such films with a powerful performance?
This should come as no surprise to anyone who has followed Downey's career. He has been in his share of middling movies, but I've never seen him work at less than full throttle. Even when he's in a lightweight vehicle like the soap-opera spoof "Soapdish" (1991), one of his early comedies, he has a radiance.
Downey's best performance remains his portrayal of Charlie Chaplin in Richard Attenborough's "Chaplin" (1992), where his intensity is paired with a lyricism that at times rivals Chaplin's own.
Downey succeeds not only because he has mastered Chaplin's movements but also because he never loses sight of the man behind the Little Tramp. His work here is a marvel of empathy.
Even before "Chaplin," Downey's work often had a Chaplinesque quality. In James Toback's "The Pick-Up Artist" (1987), he's a serial womanizer who gets his comeuppance when he falls for a gambler's daughter (Molly Ringwald). Playing a Lothario with the soul of an innocent, Downey captures the folly of romance as well as its passion.
In "True Believer" (1989), he holds his own opposite Mr. Intensity himself, James Woods. Woods plays a legendary once radical '60s lawyer who has sold out; Downey is his starry-eyed clerk, his conscience.
Downey gave a full-scale performance in Toback's "Two Girls and a Guy" (1997) as Blake Allen, a New York actor seriously involved with two girlfriends, neither of whom knows about the other until they accidentally meet in his loft (where virtually the entire film takes place). Downey is in top motormouth form here, wheedling his way in and out of half-truths with smarmy aplomb. Against all odds, he also makes the guy soulful.
Downey paired with Toback again two years later in "Black and White." Brooke Shields plays a documentary filmmaker investigating why white kids are so high on hip-hop, and Downey plays her gay husband. It's a daringly camp performance, never more so than in a comic scene where he comes on to the real-life Mike Tyson and almost gets pulverized for his troubles.
In the marvelous comedy "Wonder Boys" (2000), which stars Michael Douglas as a dissolute novelist and college professor, Downey has an indelible cameo as the writer's goateed, fop agent, who shows up for the campus literary weekend with his transvestite cohort in tow. (At the same time, and worlds apart, Downey began his celebrated two-year stint on TV's "Ally McBeal.")
In "Zodiac" (2007), Downey is a San Francisco Chronicle reporter undone by his fixation with the serial-killer case. Most obsessed characters in the movies are boring because the obsessiveness is monochromatic. Downey gives you a full palette.
He always does.
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Sunday, 1 June 2008
Cole takes time out after allegations
Girls Aloud singer Cheryl Cole has reportedly left husband Ashley for a "break" after allegations the footballer cheated on her.
Her agent insisted the couple were still together but confirmed the singer had gone on a break in order to think things through.
ITN quotes him as saying: "They are definitely still together. There is obviously lots of stuff going on at the moment and Cheryl has gone away for a break to clear her head for a few days."
It has been alleged Chelsea player Cole cheated on his wife with a hairdresser.
It has also emerged that the singer recently told OK! magazine that later this year she wanted to "start working on that baby. I want to be a young mum".
Her agent insisted the couple were still together but confirmed the singer had gone on a break in order to think things through.
ITN quotes him as saying: "They are definitely still together. There is obviously lots of stuff going on at the moment and Cheryl has gone away for a break to clear her head for a few days."
It has been alleged Chelsea player Cole cheated on his wife with a hairdresser.
It has also emerged that the singer recently told OK! magazine that later this year she wanted to "start working on that baby. I want to be a young mum".
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